Brain Res Bull. 2007 Sep 14;74(1-3):130-3. Epub 2007 Jun 28.
Papp A, Kiss EB, Tímár O, Szabó E, Berecki A, Tóth J, Páli J.
Department of Ophthalmology, Semmelweis University, Tömo u. 25-29, Budapest H-1083, Hungary. pappand@szem1.sote.hu
A silicone oil endotamponade following vitrectomy has for decades been a standard method in human ophthalmology with a view to restoring a detached retina. However, severe functional deficiencies may remain after treatment. In adult rabbits, the injection of silicone oil into the eye-ball following vitrectomy resulted in a decrease of 89% in the number of myelinated optic nerve fibres after a survival time of 1 year (418,313+/-29,703 versus 45,620+/-23,905). Concomitantly, the cross-sectional area of the optic nerve was also reduced significantly (0.853+/-0.159 mm2 versus 0.355+/-0.107 mm2). The number of non-neuronal elements of the optic nerve remained virtually unchanged immediately behind the eye-ball and in the middle part of the nerve, whereas it increased significantly close to the optic chiasm (3040+/-433 versus 3888+/-403). Thus, destruction of the myelinated optic nerve fibres is likely to be responsible for the functional deficiencies observed after silicone oil implantation.
PMID: 17683798 [PubMed - indexed for MEDLINE]